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Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delay

Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delay

Funding: -- NIH/NICHD R01
MPI:
--- Dan Ma, Deanne E Wilson-Costello, Pew-Thian Yap
Collaborators:
--- Case Western Reserve University, University Hospitals Rainbow Babies & Children's, University of North Carolina at Chapel Hill

Development of Fast Diffusion Magnetic Resonance Fingerprinting of the Prostate to Avoid Unnecessary Biopies

Development of Fast Diffusion Magnetic Resonance Fingerprinting of the Prostate to Avoid Unnecessary Biopies

Optimal detection of clinically significant prostate cancer while
avoiding overdiagnosis and unnecessary procedures

Funding:
--- NIH/NCI R01
MPI:
--- Leonardo Kaya Bittencourt, Dan Ma, Yong Chen
Collaborators:
--- Case Western Reserve University, University Hospitals Cleveland Medical Center

Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer

Development of Magnetic Resonance Fingerprinting (MRF) to Assess Response to Neoadjuvant Chemotherapy in Breast Cancer

Develop MRF methods to assess early response to neoadjuvant chemotherapy in women with breast cancer

Funding:
--- NIH/NCI R01
MPI:
--- Yong Chen, Dan Ma, Holly Marshall
Collaborators:
--- Case Western Reserve University, University Hospitals Cleveland Medical Center

MR Fingerprinting Based Quantitative Imaging and Analysis Platform (MRF-QIA) for Brain Tumors

MR Fingerprinting Based Quantitative Imaging and Analysis Platform (MRF-QIA) for Brain Tumors

Academic industry partnership to translate quantitative imaging and analysis into the clinical workflow

Funding:
--- NIH/NCI R01
MPI:
--- Dan Ma, Chaitra Badve, Christos Davatzikos
Collaborators:
--- Siemens Healthineers, Case Western Reserve University, University Hospitals Cleveland Medical Center, University of Pennsylvania

Making the Invisible Visible

Making the Invisible Visible

A multi-scale approach integrating MR imaging, tissue modeling, tissue imaging and deep learning to detect and characterize cortical pathology

Funding:
--- UK Research and Innovation/ MRC
MPI:
--- Derek Jones (contact), Dan Ma, Mark Griswold, Daniel Alexandar
Collaborators:
--- Case Western Reserve University, Cardiff University, University College London, University of Leeds

Clinically Feasible MR Fingerprinting Imaging Framework 

Clinically Feasible MR Fingerprinting Imaging Framework 

- Simultaneous T1 and T2 mapping with whole brain coverage and isotropic image resolution
- Sequence optimization using quantum optimization algorithms 
- Low rank subspace image reconstruction
- Partial volume analysis and tissue segmentation

Funding:
--- Siemens Healthineers, NIH/NIBIB R21
Collaborators:
--- Siemens Healthineers, Microsoft Quantum Team

MR Fingerprinting in Epilepsy

MR Fingerprinting in Epilepsy

Epilepsy affects 65 million people worldwide; approximately 30% of them do not respond to medications but can be cured by surgery. Focal cortical dysplasia, a major pathology for medically intractable epilepsies, are frequently missed by visual analysis of the conventional MRI, making surgical treatment very difficult. Here we propose to develop and validate novel, noninvasive and quantitative MRI acquisition and post-processing techniques, in order to guide epilepsy surgery and make more patients seizure-free.

Funding:
--- NIH/NINDS R01
MPI:
--- Dan Ma, Irene Wang
Collaborators:
--- Case Western Reserve University, Cleveland Clinic Epilepsy Center

A Framework to Design 3D MRF Scans and Reduce Patient Anxiety (MRF Music!)

A Framework to Design 3D MRF Scans and Reduce Patient Anxiety (MRF Music!)

Loud noise during MRI scans is the leading cause of patients’ anxiety, but the origin of this loud noise, mainly fast-switching fields, is also an essential component to generate images. Previous methods rely almost solely on slowing down the switching field to reduce the noise, resulting in reduced scan efficiency. We propose a general framework that could resolve this longstanding conflict by changing the sound of the MRI scan to music while simultaneously providing multiple quantitative tissue properties with high scan efficiency.

Funding:
--- NIH/NIBIB R21 Trailblazer
PI:
--- Dan Ma
Collaborators:
--- Case Western Reserve University

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